Cover Picture: Oxalyl‐CoA Decarboxylase Enables Nucleophilic One‐Carbon Extension of Aldehydes to Chiral α‐Hydroxy Acids (Angew. Chem. Int. Ed. 14/2020)

Spotlights on our sister journals: Angew. Chem. Int. Ed. 15/2018.

MAC it happen : Presented is a study of the synergistic structuredirecting effect of metal–amine complexes (MACs) with different chelating polyamine ligands and imidazolium-based ionic liquid (IL) cations. For the first time, a layered selenidostannate with an asymmetric eight-membered ring, an organic-decorated layered selenidostannate, and a 3D selenidostannate with both the MAC and IL cation...

Catalytic enantioselective nucleophilic addition of ynamides to aldehydes.

The first catalytic asymmetric addition of ynamides to aliphatic and aromatic aldehydes is described. This reaction provides unprecedented access to a diverse family of N-substituted propargylic alcohols that are obtained in high yield and ee in the presence of 10 mol% of zinc triflate and N-methylephedrine. The use of apolar solvent mixtures is essential to avoid product racemization and to op...

Reagent controlled addition of chiral sulfur ylides to chiral aldehydes

The degree of reagent and substrate control in the reaction of chiral sulfur ylides with chiral aldehydes has been investigated. Specifically, the reactions of the two enantiomers of the chiral benzyl sulfonium salt 1 with glyceraldehyde acetonide were studied in detail. Of the two new stereogenic centers created, it was found that the C1 stereochemistry was largely controlled by the reagent, w...

Cover Picture.

Chiral phosphines in nucleophilic organocatalysis

This review discusses the tertiary phosphines possessing various chiral skeletons that have been used in asymmetric nucleophilic organocatalytic reactions, including annulations of allenes, alkynes, and Morita-Baylis-Hillman (MBH) acetates, carbonates, and ketenes with activated alkenes and imines, allylic substitutions of MBH acetates and carbonates, Michael additions, γ-umpolung additions, an...